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4Life: A Legacy of Wellness, Service and Global Community

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Founded | 1998

Headquarters | Utah

Top Executives | David Lisonbee / Founder & Danny Lee / President & CEO

Product Category | Health & Wellness


The immune system is an intricate network designed to strengthen and protect. For more than 25 years, 4Life has made that the focus of their customer-centric mission. Widely recognized as The Immune System Company, its roots in science-based wellness products and a strong commitment to community empowerment, 4Life’s story is one of innovation, resilience and global impact.

A Powerful Legacy

Founded in 1998 by David and the late Bianca Lisonbee, 4Life Research began with the revolutionary immune support product, Transfer Factor. Bianca’s inspiration for the product came after she discovered early research about transfer factors—molecules that help “educate” immune cells. The couple recognized the potential of this science to improve lives and launched 4Life with a mission to promote wellness and financial opportunity.

Bianca Lisonbee’s philanthropic vision extended beyond product innovation. In 2006, she founded Foundation 4Life, a nonprofit organization dedicated to alleviating childhood poverty and empowering vulnerable communities worldwide. Over its nearly 20-year history, the Foundation has implemented service projects in more than 20 countries, including disaster relief, literacy campaigns and partnerships with organizations such as SOS Children’s Villages. Tragically, Bianca passed away in 2023, but her legacy lives on through the Foundation’s work under the leadership of her daughter, Jenna Lisonbee.

Science-First Solutions

4Life’s product line centers on immune support and wellness, with Transfer Factor as its flagship offering. “We are a science-first, product-first company,” shared Calvin Jolley, Vice President, Corporate Communications. The products are “messenger molecules” that transfer immune system memory and knowledge from one entity to another. Today, more than 50 products contain Transfer Factor, giving independent affiliates more ways to connect with customers and meet their health needs.

Customers are drawn to the brand for its commitment to innovation and quality, often forming strong relationships with 4Life’s products before transitioning to become affiliates. The company’s research-driven approach has led to a diverse product portfolio, including targeted nutritional supplements, protein powders and skincare solutions—all with a 100 percent satisfaction guarantee.

This dedication to science ensures that every product not only meets customer needs but also aligns with the company’s values of improving lives worldwide. One of the company’s key goals is to get Transfer Factor in three million homes by 2030.

Latin American Roots

A defining feature of 4Life’s growth is its deep connection with the Latin American market. The company’s first major leaders emerged in Puerto Rico and quickly expanded throughout the Spanish-speaking world. Today, Latin America remains a core focus, with Spanish serving as the company’s first operational language.

“The Latin American market has been crucial to our success,” says Founder David Lisonbee. “When a company establishes a Latin leader in the field, learn how to listen. What you think you know about the US market is quickly readjusted. Latin consumers look for different options, in products and opportunities. Ours is not a one-size-fits-all market. You must be able to segment and diversify. You must be able to appeal to this culturally unique demographic.”

Calvin says the company has always grown organically. Today, many of the top affiliates are from Puerto Rico, Mexico, Colombia, throughout South America and—of course—from coast-to-coast in the USA.

“Our largest segment is the first- and second-generation Latino market in the United States, particularly on the coasts.” This continued growth is testament to the strong leadership within the Latin American community and their ability to bring the 4Life opportunity back to the US.

Sales Force and Community Impact

At the heart of 4Life’s success is its dedicated network of affiliates. The sales force’s organic growth was built through genuine relationships rather than recruitment incentives. “People come to us as customers, and they continue their journey—if they choose to—as affiliates,” explained Danny Lee, 4Life President and CEO.

This focus fosters a strong sense of community among affiliates and customers, united by a shared belief in the product and the company’s mission. The emphasis on service, both through Foundation 4Life and local community projects, creates brand loyalty. 4Life Fortify, for example, is a nutrition program to provide children and their families with the necessary tools to become self-sufficient and discover the power to break the cycle of poverty for generations. Every purchase of 4Life Fortify is donated to Feed the Children, who then distributes the meals.

In-House Technology

As the direct selling landscape evolves, 4Life continues to leverage technology to enhance its operations and reach. From its state-of-the-art research and development facilities to the use of digital tools for affiliate training and marketing, 4Life demonstrates a commitment to staying at the forefront of industry innovation.

Nothing is off the shelf. The company built its mobile app in-house, and the affiliates’ replicated websites feature level-specific training modules and a health questionnaire for customers to answer. This helps create a targeted, personal approach to optimize their wellness with the products. Through the shop feature in the app, affiliates can share a link with anyone anywhere in the world—and immediately apply a discount to their purchase.

We have a really robust social media presence,” Calvin shared. “And everything that you expect from an IT-savvy contemporary company. We are constantly talking to our affiliates, so we know what they need. We’re on the first line in terms of what they want to best operate their business.”

4Life’s story is a powerful example of what can be achieved when science, service and community come together. The company’s unwavering dedication to improving lives through innovative products and global philanthropy has established it as a leader in both wellness and direct selling. With its roots firmly planted in the vision of its founders and its eyes set on the future, 4Life continues to inspire and empower individuals worldwide.

From the January/February 2025 issue of Direct Selling News magazine.

The Real Brokerage Celebrates 25,000 Agents Milestone

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The Real Brokerage Inc. announced it now serves 25,000 agents. The technology platform designed to reimagine the real estate buying process for agents, buyers and sellers welcomed approximately 1,000 new agents each month in 2024, and anticipates January 2025 to be its fastest-growing month in company history.

The company’s agent-focused programs have been a catalyst for the company’s growth. Programs Private Label and ProTeams, for instance, focus on serving independent brokerages and large teams while allowing them to maintain their own brands and existing compensation structures. Real Wallet, the company’s fintech platform, centralizes an agent’s access to company-branded financial products and allows agents to open a business checking account, with access to tax planning business checking accounts and revenue sharing expected to launch in the near future.

“Our mission and our vision from day one has been to make agents’ lives better,” said Tamir Poleg, Real Founder, Chairman and CEO. “I’m thankful to our leadership team and the Real employees who wake in the morning and go to sleep at night with our agents in mind. We couldn’t have reached this milestone without each member of our collective community. I am also grateful to the growing number of agents who have chosen to partner with us. Although 25,000 feels like a big number, we are just getting started, and their partnership and the trust they have placed in Real means everything.”

The Real Brokerage Inc. has a presence in all 50 US states and four Canadian provinces.

PM-International Breaks Ground on its HQ Americas

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PM-International hosted a groundbreaking event at its new HQ Americas in Florida. The new facility is expected to serve as a hub for PM-International business in the Americas and is part of the company’s stated vision to exceed $1 billion in sales in the region and $5 billion in global revenue by 2027.

“This expansion marks an exciting chapter for PM-International in the Americas,” said Denzel Bock, PM-International General Manager of Sales for the USA. “By establishing a state of-the-art facility in Florida, we’re not only enhancing our operational efficiency but also creating a stronger foundation to support our growing network of partners and customers. This strategic move positions us to meet the increasing demand for our FitLine products.”

PM-International is expected to invest in this infrastructure in three phases. The initial investment is expected to cost $22 million, including $9.5 million to secure construction grounds for the new headquarters and warehouse space, with a total investment of $50 million after the completion of the second and third phases.

The new facility will feature sustainability-minded elements, including energy-efficient lighting, advanced HVAC systems, and renewable energy technology to reduce its carbon footprint, and will host administrative offices, a flagship direct sales center, fulfillment center, an in-house quality control lab and GMP Production to streamline distribution of its FitLine health and wellness products, all of which is expected to create 400-500 new jobs for the local economy.

“Our new facility in Florida is more than just an expansion; it is a statement of our dedication to our growth plans in the Americas and our belief in its potential,” said Rolf Sorg, PM-International Founder & CEO. “Today, we are starting the next chapter of PM-International’s journey in the Americas. This investment reflects our core mission of improving lives, both through our premium products and through the economic opportunities we create.”

Le-Vel Debuts GLP-1 Weight Management Solution

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Le-Vel announced the launch of its myGLP dietary supplement system, a four-party weight management system that leverages the body’s naturally occurring GLP-1 hormones. This new product comes in the form of a dietary supplement that, unlike many competitors, comes in a non-invasive option that does not require needles or prescriptions.

The myGLP system includes:

  • myGLP Capsules – designed to boost mental clarity and energy while curbing appetite
  • myGLP Shake – a nutrient-focused meal replacement
  • myGLP Oral Strips – fast-dissolving natural GLP-1 support
  • myGLP DFT – wearable nutrition to support natural GLP-1 levels

Le-Vel described its new myGLP system as unique in that it focuses on creating healthier, more balanced futures for its customers, rather than short-term results. The company has also partnered with third-party laboratories to study and validate the myGLP system’s results.

“This is more than a product launch,” said Jason Camper, Le-Vel Founder and CEO.  “It’s the beginning of the next chapter for Le-Vel and for the entire health and wellness industry. We’re here to create solutions that are natural, sustainable and truly life-changing.”

Tupperware to Withdraw from Europe

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Tupperware Brands announced its official exit from Europe. Germany, which was at one time the company’s strongest market, has officially closed and business activities have been discontinued.

Sources close to Tupperware predict that the company will now focus its efforts on its core markets in North, Central and South America, as well as India and China.

Tupperware closed its only US manufacturing hub in June 2024 and announced it would file for bankruptcy in September 2024 after entering into a forbearance agreement with lenders in February of the same year. In October 2024, the company emerged as The New Tupperware Company and stated it would rebuild the organization with a “start-up mentality using an agile methodology in dynamic phases.”

dōTERRA Foundation Provides Relief for California Wildfire Victims

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dōTERRA Healing Hands, the philanthropic organization for dōTERRA, sent 6,950 relief kits to those affected by the wildfires spreading across California. dōTERRA Wellness Advocates distributed the kits which are designed to address immediate needs for those who are suffering, and include personal care items, essential wellness products and comforting supplies.

dōTERRA applauded its Wellness Advocates for participating in what it called a “rapid mobilization” to assemble 72-Hour Emergency Relief Hygiene Kits at the dōTERRA Lindon Fulfillment Center.

“Our hearts go out to everyone who has been affected by these tragic wildfires,” said Misty Bond, dōTERRA Vice President of Corporate Relations and Philanthropy. “At dōTERRA, we believe in the power of community and resilience. The compassion and dedication shown by our Wellness Advocates and team members are truly inspiring, and we are honored to stand with the families impacted by this crisis as they rebuild their lives.”

Epicure Announced that it had Ceased Operations

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On January 24, in a letter to their ambassador community, Epicure Founder and Owner Sylvie Rochette announced that Epicure would cease operations immediately. 

Epicure was founded 32 years ago with a mission to empower others to prioritize their health without compromise by supporting time-starved families in creating nourishing meals.

Rochette expressed her sadness and thanked everyone for being part of the extraordinary journey. Financial challenges left over from the pandemic were cited as a contributing factor to the decision. 

“Thank you for being part of this extraordinary journey and for your support, trust and loyalty over the years.  I will forever cherish the impact we’ve made together,” wrote Rochette.

This is yet another part of a larger pattern of companies exiting or modifying their direct selling model.  It follows just three months after the notice from Thirty-One Gifts. 

eXp Realty Named to Glassdoor’s Best Places to Work List

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eXp Realty was included in Glassdoor’s list of Best Places to Work for the eighth consecutive year. This year, the company significantly increased its ranking in the 100 companies featured – from No. 22 last year to No. 7 this year.

Recognized companies are ranked based on employee ratings across a number of workplace attributes, including career opportunities, compensation and benefits, culture and values, senior management, diversity and inclusion, and work/life balance.

“Our recognition as one of Glassdoor’s Best Places to Work for the eighth consecutive year – and our remarkable leap to No. 7 this year – is a testament to eXp Realty’s unwavering commitment to creating an agent-centric environment and fostering satisfaction among our agents and staff alike,” said Leo Pareja, eXp Realty CEO. “At eXp, we prioritize innovation, collaboration, and growth opportunities that empower our team to thrive, and this honor reflects the passion and dedication of our entire eXp community. We remain steadfast in our mission to redefine real estate by putting our people first, who in turn take exceptional care of their clients.”

eXp Realty earned a 4.5 rating out of a possible 5 on Glassdoor’s company review list, an estimated 21% higher rating than is average within the real estate industry.

LifeVantage Wins Innovation Award at Best in Biz Event

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LifeVantage Corporation and its TrueScience Activated Skincare Collection was recognized with a silver award for Most Innovative Product Line at the Best in Biz Awards 2024. The TrueScience Activated Skincare Collection was selected by a panel of editors and reporters from North American publications and chosen because it stood out for its creativity and impact.

“This award is a testament to LifeVantage’s unwavering drive to push boundaries and redefine what’s possible in health and wellness, including skin health,” said Steve Fife, LifeVantage President and CEO. “The TrueScience Activated Skincare Collection embodies our mission to merge cutting-edge activation science with clean, safe formulations that work at the cellular level of the skin to empower people to look and feel their best. We’re honored to be recognized and inspired to continue creating products that make a difference in people’s lives.”

The TrueScience Activated Skincare Collection includes hero products TrueRenew Daily Firming Complex and TrueHydrate Brightening moisturizer and utilizes clean, science-backed ingredients.

Maximize Your Event Budget

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The best show doesn’t always require the biggest budget.

Planning an event involves balancing creativity and fiscal responsibility. A well-allocated budget can enhance the attendee experience while keeping costs manageable. Below are key strategies to help you get the most out of your event budget.

Understand Your Venue Contract

Venues often offer incentives such as reduced room rental rates or discounted food and beverage packages to win your business. However, failing to carefully review the contract before signing can lead to unnecessary expenses later. Key areas to scrutinize include exclusivity charges for rigging, production, printing and installation.

For example, rigging—a critical component in many events—can vary significantly in cost based on exclusivity agreements. In a non-exclusive venue, rigging may account for three to eight percent of your budget. However, in exclusive venues, rigging costs can skyrocket to 15-20 percent of the production budget.

Jacob Lund/shutterstock.com

To illustrate:

  • A single half-ton chain hoist in a non-exclusive venue, $225-265 per week.
  • The same hoist in an exclusive venue, $300-400 per day—often billed for the entire event duration.

At a medium-sized event, this difference could mean paying $30,000 versus $3,700 for the same rigging setup. By understanding these costs upfront, you can better evaluate the true value of your venue contract.

Compact Your Schedule

Efficient scheduling and room usage can yield significant savings.

  • Rehearsals: Conduct initial read-throughs at your office or in a meeting room instead of the main stage. This reduces the hours spent on costly on-sight adjustments with a full crew. Main stage time should focus on fine-tuning the performance, not revising scripts or graphics.
  • Room Usage: Maximize the utility of your General Session room by hosting breakouts, mixers or other events there. Consolidating activities into one space reduces the need for additional setups, allowing more budget for impactful elements in your primary room.

Reuse and Repurpose Fabrications

Custom fabrication adds a unique touch to events but can become a budgetary black hole if not planned wisely.

  • Invest in Evergreen Fabrications: Opt for designs that can be reused across events. For instance, custom client logos or stage enhancements can be touched up or repurposed for future use, saving significant costs.
  • Plan for Reuse: Work with your production partner to store and repurpose large builds, such as expo installations or stage props. This reduces the need to rent new items for subsequent events while enriching your expo or stage experience over time.
DeshaCAM/shutterstock.com

Stay Organized and Start Early with a Trusted Partner

Effective communication and organization are the foundation of a well-managed budget. Ensure alignment between your team and production partners. Remember:

  • You know your organization’s culture and goals.
  • Your production partner has the expertise to optimize event logistics and maximize impact.

Rather than just looking for the best deal in the moment, you should aim to cultivate relationships with vendors you can rely on year after year. Long-term partners who know your preferences and expectations can also suggest cost-effective alternatives when needed.

Additionally planning and understanding needs and budgets early can help you and your production partner in sourcing and negotiating with vendors. It is much easier to ask for a discount or for a vendor to match pricing etc., when you are several months ahead of the event.

Collaboration and mutual understanding can turn a good event into a memorable one without unnecessary overspending. 

Scott Beelman, Co-Founder and SVP of Production at Katapult Events, is an out-of-work bass player who had to rely on his fallback option in the events industry once his mediocre (at best) career as a professional musician dried up. Fifteen years later he’s still looking for that last gig, but he’s learned a thing or two about producing direct sales events.

From the January/February 2025 issue of Direct Selling News magazine.

eXp Realty Founder Rings NASDAQ Bell

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eXp World Holdings, the holding company for eXp Realty, was invited to the Nasdaq MarketSite in Times Square to celebrate the company’s growth and innovation. Glenn Sanford, eXp World Holdings Founder, Chairman and CEO, and Leo Pareja, eXp Realty CEO, rang the Opening Bell as part of the event.

During the livestream following the event in New York City, Sanford spoke to eXp executives, agents and team leaders, declaring “bold” the word of the year for eXp’s mission and goals in 2025.

“Bold moves lead to unexpected opportunities. Focus on the right things, and great outcomes follow,” Sanford said.

Pareja also addressed the livestream audience, emphasizing the company’s unique model and opportunity during the livestream.

“We invented this category,” Pareja said. “Our first priority is operational excellence, and we are here to empower agents to go faster, stronger, and better in serving families with their most important financial decisions.”

4Life Executive Named to American Association of Immunologists

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Dr. David Vollmer

4Life Chief Scientific Officer Dr. David Vollmer has been named a member of the American Association of Immunologists (AAI). This membership is exclusive to individuals who hold a Ph.D. in immunology or related discipline, have authored at least one peer-reviewed journal article, and who are approved and invited by the AAI.

Dr. Vollmer now joins the AAI’s mission to improve global well-being through the advancement of immunological sciences by inspiring and educating immunologists and advocating for the necessary resources to advance immunological enterprises.

“Membership in the American Association of Immunologists reflects 4Life’s commitment to scientific inquiry, patent protection, and peer-reviewed publication—all of which combine to ensure complete customer satisfaction,” Dr. Vollmer said. “I’m honored to represent the company as a member of this reputable association.”